Our Solution
ClotGuard combines freeze-dried platelet technology with precision nanobots to deliver autonomous bleeding control directly at the wound site.
Platelet Preparation
Platelets are harvested and freeze-dried to preserve them in a stable, dormant state. This process removes water content while maintaining their natural clotting properties, ready to activate instantly when needed.
Nanobot Delivery System
Tiny biodegradable nanobots carry the freeze-dried platelets through the bloodstream. Made from biocompatible materials, they navigate precisely to the injury site without harming surrounding tissue.
Biomarker Detection
Onboard sensors detect key bleeding indicators in real time. These biological signals work together to pinpoint the exact location of injury and trigger the response system.
Targeted Platelet Release
Upon reaching the wound site, nanobots release the platelets to initiate clotting. The entire process from detection to clot formation can occur in as little as 2-5 minutes, providing critical early intervention.
From Detection to Clotting
The wearable patch contains sensors that continuously monitor for bleeding biomarkers. When these indicators exceed critical thresholds near damaged tissue, the system activates the platelet-loaded nanobots stored within the patch.
The nanobots navigate through the bloodstream following biological signals to the injury site. Upon arrival, they release their platelet cargo to rapidly initiate clot formation -- all without any manual intervention.
The Need Has Never Been Greater
Rising trauma cases and persistent delays in emergency care highlight the urgent need for autonomous bleeding control. Advances in biosensor technology, biocompatible materials, and microneedle delivery systems have finally made this possible.
Reduce Preventable Deaths
Target the leading cause of preventable death in trauma situations worldwide.
Faster Emergency Response
Enable life-saving treatment in the critical moments before first responders arrive.
Global Accessibility
A wearable solution that can be deployed anywhere, from urban centers to remote areas.
The ClotGuard One-Pager
Everything you need to know about ClotGuard in a single page. From our freeze-dried platelet technology and nanobot-powered delivery system to real-world impact metrics, this document covers how ClotGuard works and why it matters.
Download our one-pager for a comprehensive overview of the technology, our process, and the advantages ClotGuard brings to emergency bleeding control.
Download One-Pager (PDF)
Validated by Science
ClotGuard's concept is grounded in over 100 peer-reviewed publications spanning stimuli-responsive drug delivery, platelet-membrane biomimetics, hemostatic nanomaterials, and biosensor-triggered therapeutics. Beyond the literature, we have consulted with dozens of professors and PhD holders in biomedical engineering, hematology, and nanotechnology who have validated our approach.
Stimuli responsiveness of recent biomacromolecular systems (concept to market): A review
Singh, D., Sharma, Y., Dheer, D., Shankar, R.
International Journal of Biological Macromolecules, 2024
Platelet-derived membranes as biomimetic interfaces for engineering functional nanocarriers
Coradduzza, D., Vecciu, B., Cadoni, M.P.L., et al.
Biomaterials Science, 2025
Nano-safety guardians: Surface engineering strategies for building hemocompatible shields
Cai, X., Chen, H., Peng, Z., et al.
Applied Surface Science Advances, 2025
A Sprayable Hydrogel Based on Biomimetic Polypeptide-Modified Lipid Nanoparticles for Non-Compressible Hemorrhaging
Feng, Y., Zhang, Z., Yan, W., et al.
Advanced Materials, 2025
Modulating Nanoparticle Size to Understand Factors Affecting Hemostatic Efficacy
Hong, C., Alser, O., Gebran, A., et al.
ACS Nano, 2022
Intraosseous administration of lyophilized synthetic platelets renders hemostatic efficacy
Liu, Z., Abdullah, A., Secunda, Z.A., et al.
Journal of Thrombosis and Haemostasis, 2025
Modulating Coagulation via Bioinspired Mesoporous Calcium-Decorated Silica Nanoparticles
Ms, M., Venkatasubbu, G.D.
ACS Applied Bio Materials, 2024
Calcium-based nanoparticles accelerate skin wound healing
Kawai, K., Larson, B.J., Ishise, H., et al.
PLoS ONE, 2011
Controllable Thrombolysis Using a Nanobubble-Imaging-Guided rtPA Targeted Delivery Strategy
Tang, J., Xu, H., Li, M., et al.
BME Frontiers, 2024
From bench to bedside: Platelet biomimetic nanoparticles as promising carriers for personalized drug delivery
Safdar, A., Wang, P., Muhaymin, A., et al.
Journal of Controlled Release, 2024
Porous gelatin microspheres for controlled drug delivery with high hemostatic efficacy
Cao, S., Li, L., Du, Y., et al.
Colloids and Surfaces B: Biointerfaces, 2021
Targeted Hybrid Theranostic Nanocarriers Enhance Thrombolytic Therapy
Gao, M., Lu, J., Liang, J., et al.
ACS Applied Materials and Interfaces, 2025
Showing 12 of 112 referenced publications. Our full reference list spans stimuli-responsive drug delivery, platelet-membrane biomimetics, calcium-based hemostatics, nanocarrier engineering, and wound-responsive smart materials.